Recent epidemiologic evidence suggests that there is a narrow range of vitamin D levels in which vascular function is optimized. Vitamine D, besoins et carences. Symptomatic vitamin D toxicity is uncommon, and elevated levels of 25(OH)D do not strongly correlate with clinical symptoms or total serum/plasma calcium levels. This video describes some possible mechanisms by which vitamin D may cause toxicity. Studies on the South Asian population uniformly point to low 25(OH)D levels, despite abundant sunshine. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. These are three of the current theories discussed in this video: 1. [45][46], Long-term effects of supplementary oral intake, [Effects Of Vitamin D and the Natural selection of skin colour:how much vitamin D nutrition are we talking about, Scientific Advisory Committee on Nutrition (2007) Update on Vitamin D Position Statement by the Scientific Advisory Committee on Nutrition 2007, "Comparison between the protective effects of vitamin K and vitamin A on the modulation of hypervitaminosis D3 short-term toxicity in adult albino rats", "Vitamin D toxicity redefined: Vitamin K and the molecular mechanism", "The 2011 Report on Dietary Reference Intakes for Calcium and Vitamin D from the Institute of Medicine: What Clinicians Need to Know", "Dietary Reference Intakes Tables [Health Canada, 2005]", "Environmental factors that influence the cutaneous production of vitamin D", http://www.direct-ms.org/pdf/VitDVieth/Vieth%20Anthropology%20vit%20D.pdf, "Human plasma transport of vitamin D after its endogenous synthesis", "Seasonal variance of 25-(OH) vitamin D in the general population of Estonia, a Northern European country", "Out of Africa: modern human origins special feature: the spread of modern humans in Europe", "Controversies in Vitamin D Supplementation", "Vitamin D and osteogenic differentiation in the artery wall", "Investigation of the potential association of vitamin D binding protein with lipoproteins", "Vascular calcification: pathobiology of a multifaceted disease", "Vitamin d, adiposity, and calcified atherosclerotic plaque in african-americans", "1alpha(OH)D3 One-alpha-hydroxy-cholecalciferol--an active vitamin D analog. Clinical manifestations of vitamin D toxicity are varied, but largely related to hypercalcemia and include neuropsychiatric (such as confusion, psychosis, stupor, or coma), gastrointestinal (abdominal pain, vomiting, polydipsia, anorexia, constipation, pancreatitis), cardiovascular (hypertension, shortened QT interval, ST segment elevation, bradyarrhythmias, first degree heart block), and renal (hypercalciuria, … Vitamin D toxicity, also called hypervitaminosis D, is a rare but potentially serious condition that occurs when you have excessive amounts of vitamin D in your body. Vitamin D. Office of Dietary Supplements. Vitamin D is essential for the metabolism and stable equilibrium of calcium and phosphate—elements that are necessary for the growth and development of bones and teeth. Our study highlights the potential risks of the liquid formulation of vitamin D. Abstract Fortification of food products with vitamin D was central to the eradication of rickets in the early parts of the 20th century in the United States. https://www.hormone.org/diseases-and-conditions/hypercalcemiaAccessed March 20, 2020. If people aren't getting enough Vitamin D, why not just pump it right into them with pills? Recommended Dietary Allowance (RDA) for most adults of 600 IU of vitamin D a day. Vitamin D helps regulate the amount of calcium and phosphate in the body. [37][38] These levels were described to be 75 nmol/L as "optimal", between 75 nmol/L and 50 nmol/L as "insufficient" and < 50 nmol/L as "deficient". This content does not have an Arabic version. This content does not have an English version. All rights reserved. [citation needed] Acute overdose requires between 15,000 µg/d (600,000 IU per day) and 42,000 µg/d (1,680,000 IU per day) over a period of several days to months. [11], It has been questioned whether to ascribe a state of sub-optimal vitamin D status when the annual variation in ultraviolet will naturally produce a period of falling levels, and such a seasonal decline has been a part of Europeans' adaptive environment for 1000 generations. Accessed March 20, 2020. Although toxicity is considered possible above 100 ng/ml, most cases of vitamin D toxicity occur at even higher levels than this, usually above 200 ng/ml. vitamin D toxicity because it causes symptoms. Vitamin D toxicity is rare and may often go unrecognized, according to Catharine Ross, a professor of nutrition and physiology and head of Nutritional Sciences at Pennsylvania State University. Blood levels should be monitored while someone is taking high doses of vitamin D. As always, talk to your doctor before taking vitamin and mineral supplements. Frontiers in Endocrinology. Long-term ingesting of vitamin D supplements above the maximum dosage for a certain age will lead to various adverse health effects and even to the development of vitamin D toxicity. [2] Symptoms of vitamin D toxicity may include the following: Symptoms of vitamin D toxicity appear several months after excessive doses of vitamin D are administered. Vitamin D toxicity is extremely rare, but does occur with extreme doses. Vitamin D: Can it prevent Alzheimer's & dementia? [11] In contrast, orally administered vitamin D produces rapid hepatic delivery of vitamin D and increases plasma calcifediol. In almost every case, a low-calcium diet combined with corticosteroid drugs will allow for a full recovery within a month. Overdose has been observed at 1,925 µg/d (77,000 IU per day). Vtamin D overdose symptoms are primarily caused … 22% of individuals of European ancestry had 25(OH)D levels less than the 40 nmol/L cutoff, comparable to the values observed in previous studies (40nmol/L is 15 ng/mL). [20][24][25][26] Higher levels of calcidiol positively correlate with aorta and carotid calcified atherosclerotic plaque in African Americans but not with coronary plaque, whereas individuals of European descent have an opposite, negative association. [20] There are racial differences in the association of coronary calcified plaque in that there is less calcified atherosclerotic plaque in the coronary arteries of African-Americans than in whites. A single copy of these materials may be reprinted for noncommercial personal use only. [28][29][30][31], Recommendations stemming for a single standard for optimal serum 25(OH)D concentrations ignores the differing genetically mediated determinates of serum 25(OH)D and may result in ethnic minorities in Western countries having the results of studies done with subjects not representative of ethnic diversity applied to them. [9] This process is less efficient with increased melanin pigmentation in the skin. [27], Among descent groups with heavy sun exposure during their evolution, taking supplemental vitamin D to attain the 25(OH)D level associated with optimal health in studies done with mainly European populations may have deleterious outcomes. [19][20], The levels of the active form of vitamin D, calcitriol, are inversely correlated with coronary calcification. FREE book offer – Mayo Clinic Health Letter, Vitamin D toxicity - What if you get too much. Advertising revenue supports our not-for-profit mission. 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